Research

Orthopedic Implant Design & Robotic-Assisted Surgery

Engineering Precision and Innovation in Joint Replacement

Dr. Arshi’s research bridges orthopedic surgery and bioengineering to advance the design and safety of hip and knee replacements. His work focuses on developing and evaluating surgical technologies and implant materials that improve precision, biomechanics, and long-term implant performance.

Through collaboration with experts in robotics, tissue engineering, and materials science, Dr. Arshi’s research translates technological advances from the lab to the operating room to help patients achieve more predictable outcomes.

Focus Areas

• Robotic and computer-navigated arthroplasty – studying how robotic-assisted systems improve surgical accuracy, reproducibility, and alignment in total joint replacement.
• Implant design and fixation mechanics – analyzing implant geometry, fixation methods, and materials to enhance joint stability and longevity.
• Bioengineering and tissue-engineered constructs – exploring polymer scaffolds, biologic coatings, and controlled growth factor release systems to promote healing, bone integration, and infection eradication.
• Technology-driven personalization – using 3D imaging and data analytics to optimize implant selection and surgical planning for each patient.

Together, these studies combine engineering precision with biologic innovation to guide the next generation of arthroplasty design and technique.

Representative Publications

1. Anil U, Di Gangi C, Anderson L, Lin CC, Hepinstall M, Meftah M, Arshi A.
   Coronal Alignment Does Not Adequately Predict Femoral Rotation Axes in Total Knee Arthroplasty: Application of a 3D Image-Based Robotic-Assisted Arthroplasty Platform.
   Bioengineering (Basel). 2025; 12(7):727. PMID: 40722420
2. Rajahraman V, Haider MA, Saba BV, Rozell JC, Schwarzkopf R, Arshi A.
   Do Differences in Patient-Reported Outcome Measures for Robot-Assisted and Navigated Unicompartmental Knee Replacement Achieve Minimal Clinically Important Differences?
   Surg Technol Int. 2025. PMID: 40632911
3. Ward SA, Habibi A, Ashkenazi I, Arshi A, Meftah M, Schwarzkopf R.
   Innovations in the Isolation and Treatment of Biofilms in Periprosthetic Joint Infection: A Comprehensive Review of Current and Emerging Therapies in Bone and Joint Infection Management.
   Orthop Clin North Am. 2024; 55(2):171–180. PMID: 38403364
4. Arshi A, Sekimura T, Kelley BV, Zeegen EN, Lonner JH, Stavrakis AI.
   Navigated and Robot-Assisted Technology in Total Knee Arthroplasty: Do Outcome Differences Achieve Minimal Clinically Important Difference?
   J Arthroplasty. 2022; 37(8):1562–1569. PMID: 35367335
5. McPherson EJ, Sherif SM, DiPane MV, Arshi A.
   Patellar Rebar Augmentation in Revision Total Knee Arthroplasty.
   J Arthroplasty. 2021; 36(2):670–675. PMID: 32951925
6. Leong NL, Kabir N, Arshi A, Nazemi A, Wu BM, Petrigliano FA, McAllister DR.
   Use of Ultra-High Molecular Weight Polycaprolactone (UHMW-PCL) Scaffolds for ACL Reconstruction.
   J Orthop Res. 2016; 34(5):828–835. PMID: 26497133
7. Leong NL, Kabir N, Arshi A, Nazemi A, Wu B, Petrigliano FA, McAllister DR.
   Evaluation of Polycaprolactone Scaffold With Basic Fibroblast Growth Factor and Fibroblasts in an Athymic Rat Model for Anterior Cruciate Ligament Reconstruction.
   Tissue Eng Part A. 2015; 21(11-12):1859–1868. PMID: 25744933
8. Leong NL, Arshi A, Kabir N, Nazemi A, Wu BM, Petrigliano FA, McAllister DR.
   In Vitro and In Vivo Evaluation of Heparin-Mediated Growth Factor Release From Tissue-Engineered Constructs for Anterior Cruciate Ligament Reconstruction.
   J Orthop Res. 2015; 33(2):229–236. PMID: 25363620

Journals Featuring Dr. Arshi’s Work

• Journal of Arthroplasty
• Bioengineering
• Orthopaedic Clinics of North America
• Journal of Orthopaedic Research
• Tissue Engineering
• Journal of Bone and Joint Surgery
• Journal of the American Academy of Orthopaedic Surgeons

Translational and Clinical Impact

Dr. Arshi’s work integrates engineering innovation and clinical science to redefine precision and quality in joint replacement. His studies on robotic-assisted surgery help improve alignment accuracy and consistency, while his bioengineering collaborations explore next-generation materials and biologic delivery systems that enhance implant integration and tissue healing.

Through this multidisciplinary approach, Dr. Arshi continues to advance the future of hip and knee arthroplasty — combining technology, biologic science, and patient-centered care to achieve safer, longer-lasting outcomes.

Full Publication List

For a complete and up-to-date list of Dr. Arshi’s publications, please visit his PubMed profile here.

Explore More Research

Dr. Arshi’s work on return to sport is just one aspect of his broader research portfolio in hip and knee replacement surgery.
Explore all research focus areas